LRH-1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype.

Consistent with our previous results (Figure 6 ), IFNγ secretion and expression levels were reduced in BL001‐treated co‐cultures of PBMCs with hiPSC‐derived islet organoids, although the former did not reach statistical significance (Figure 7F,G ).

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