Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment.

Notably, high IL1RAP expression on tumor cells and stroma combined, was associated with a significantly increased progression-free survival (median: 3.5 vs 1.2 months, p=0.0023) and showed a trend toward extended overall survival (median: 5.0 vs 2.2 months, p=0.1136) with a follow-up of 11.5 months ( figure 7B ).

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