Protein kinase R induced by type I interferons is a main regulator of reactive microglia in Zika virus infection.

Glia · 2025 · PMC11660536 · PMID 39359232

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nearly significantno p-value reported

Although significant, the effect of iPKR treatment on the expression of genes associated with a pro‐inflammatory response induced following ZIKV brain infection was not total and the effect on Irf1 expression was only nearly significant suggesting the contribution of a mechanism independent of PKR.

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