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Germline variants of homology-directed repair or mismatch repair genes in cervical cancer.

Int J Cancer · 2025 · PMC11661519 · PMID 39440754

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12 , 13 While this did not reach statistical significance, our findings confirm that a substantial proportion of cervical cancer patients harbour pathogenic HDR gene variants, in line with the results by Wen et al. 14 Interestingly, this fraction of cases did not explain HPV‐negative cervical cancer because all HDR variants except one (a FANCM variant) were identified in HPV‐positive cases in our study.

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