Operationalizing the New Global Definition of ARDS: A Retrospective Cohort Study From South Africa.

Patients without COVID-19 meeting only the global definition of ARDS criteria showed reduced ICU mortality (14.2% [95% CI, 11.6%−16.9%] vs 22.2% [95% CI, 19.8%−24.6%]; OR, 0.58 [95% CI, 0.45–0.75]; P < .0005) compared with patients without COVID-19 meeting the Berlin definition of ARDS, whereas patients with COVID-19 meeting only the global definition of ARDS criteria showed a suggestion of increased ICU mortality that did not reach statistical significance (58.6% [95% CI, 51.0%−66.2%] vs 48.7% [95% CI, 34.1%−63.3%]; OR, 1.55 [95% CI, 0.74–3.24]; P = .25) compared with patients with COVID-19 meeting the Berlin definition of ARDS.

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