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Booster COVID-19 mRNA vaccination ameliorates impaired B-cell but not T-cell responses in older adults.

Front Immunol · 2024 · PMC11663736 · PMID 39717779

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The numbers of AIM + spike-specific CD8 + T cells in older adults after the first dose (in the primary response) tended to be lower than those in adults, although the difference did not reach statistical significance in this study likely because of the limited sample size (n=67) compared to the previous study (n=216) ( 12 ) ( Figure 4A ).

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