Comparative assessment of the transduction efficiency and safety associated with the delivery of AAV9-GFP vector via lumbar puncture to cynomolgus macaques with and without anti-AAV9 pre-existing antibodies.

One of the protein markers with the most disrupted content in the serum was FK506 binding protein 1B ( FKBP1B ) , with a content level that increases by 7.6-fold in seropositive monkeys versus 1.46 in their seronegative counterparts, a trend that did not reach statistical significance ( p = 0.143) ( Figure 6 C).

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