The sEH‐phos del mice showed a trend toward increased levels of 2‐arachidonoyl‐LPA (2‐A‐LPA) (Fig. 4A ) and decreased levels of 2‐arachidonoyl glycerol (2‐AG) (Fig. 4B ) compared to the WT.
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Mice deficient in the phosphatase activity of sEH show decreased levels of the endocannabinoid 2-AG in the olfactory bulb and depressive-like behavior.
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