Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease.

Except for one variant located at 37,927,476 bp, all MICALL1 variants included in this test have MAF < 0.005 and were protective (OR = 0.26 to 0.41) and nominally significant ( p < .05) (Table 5 ).

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111 Although the association of this variant with AD did not quite reach statistical significance in our study ( p = 8.05×10 −2 ), another SHARPIN variant (rs34173062) that is frequent in European populations but absent in East Asians was significantly associated with AD in large European ancestry samples evaluated using multiple approaches. 17 , 112 A Japanese study reported GWS associ

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