Mpox mRNA-1769 vaccine inhibits orthopoxvirus replication at intranasal, intrarectal, and cutaneous sites of inoculation.

The mean NT50 values in the sera of mice one day after inoculation were in the order ACAM3000 < ACAM2000 < 15 μg mRNA, <50 μg mRNA, <150 μg mRNA and protection to the VACV challenge was directly proportional to the antibody titers, although the differences in NT50s between ACAM3000, ACAM2000 and 15 μg of mRNA did not reach statistical significance.

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