Transmembrane and coiled-coil 2 associates with Alzheimer's disease pathology in the human brain.

Down syndrome temporal gyrus showed an increase in the centrally migrating form of TMCC2 compared to late onset AD and familial AD; however, the differences in ratios of TMCC2 forms between temporal gyrus and cerebellum did not reach statistical significance (Figure 5F ), potentially because of sample numbers being underpowered.

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