In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration.

JOR Spine · 2024 · PMC11669629 · PMID 39726900

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0810

boldest claim

The sentences

approached significancep = 0.051so close (0.05 < p ≤ 0.1)

FLR‐miRNA mimics 140 + 149 approached significance ( p = 0.051) for aggrecan deposition.

also in 1,711 other papers

a positive trendp = 0.081so close (0.05 < p ≤ 0.1)

Immunofluorescence quantification demonstrated transfection with miRNA‐140 mimic significantly enhanced aggrecan deposition following transfection with FLR ( p = 0.015), and collagen II protein production was significantly increased by RALA delivery ( p = 0.014), with a positive trend for FLR ( p = 0.081) (Figure 1A,B ).

also in 3,489 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.