Nevertheless, the cohort showed a trend towards separation by recurrence status using this set of differentially expressed genes (DEGs) in a principal component analysis (PCA) plot ( Figure 1B ) and with hierarchical clustering ( Supplementary Figure S1 ) and high Pearson correlation coefficient ( Supplementary Figure S2 ).The most significant DEG was GSTM1 ( Figure 1C ) that was downregulated in recurrent tumors.
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<i>GSTM1</i> null genotype underpins recurrence of <i>NF2</i> meningiomas.
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