An Advanced Mechanically Active Osteoarthritis-on-Chip Model to Test Injectable Therapeutic Formulations: The SYN321 Case Study.

HPC also caused a significant increase in MMP13 expression and a decreasing trend in ACAN expression.

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On study days 14 and 17, treatment with either dose level of SYN321 showed a trend of reduction in the weight‐bearing difference between the two hind legs compared to the saline‐treated group.

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Specifically, PTGS2 , a gene encoding for the enzyme COX‐2, and IL6 were significantly upregulated in the OA samples with respect to controls, while the pro‐inflammatory gene TNF showed an increasing trend.

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uBeat MultiCompress ® Enables to Elucidate the Efficacy of SYN321 to Reduce OA Traits under Hyperphysiological Mechanical Load Upon evidence of a positive trend of SYN321 in alleviating symptoms in the MIA model, the previously qualified uBeat MultiCompress platform was used to dissect the cellular and molecular mechanisms underlying SYN321 effect.

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