WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration.

Moreover, the number of Ki67-positive cells increased in Wnt4 -knockdown organoids while decreased in Wnt4 -overexpressing organoids, in both the bud and non-bud areas, compared with their respective controls, although the non-bud areas did not reach statistical significance (Fig. 1 E, F ), suggesting that WNT4 inhibits the proliferation of organoids.

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