nominally significantp = 0.743
For each of these domains, the difference in percentage of cases and controls reporting problems with worsening symptoms were not even nominally significant: 31.74% versus 23.08% (psychosocial; p = 0.743 by a Fisher test), 52.27% versus 66.67% (bone; p = 0.674 by a Fisher test), and 35.71% versus 16.67% (gastrointestinal; p = 0.285 by a Fisher test). 3.4 Ovarian outcomes Previous studies of girls and young women with CG have revealed the extraordinary prevalence of premature ovarian insufficiency in this population. 4 , 10 , 23 , 24 Here, we asked female participants about their current and prior outcomes related to ovarian function, and about any experiences with pregnancy.