Based on micro-CT analysis on these founder mice, Cartpt deletion showed a trend toward to decreased trabecular bone volume in femurs in a dosage-dependent manner (biallelic showed a greater reduction of bone mass compared with monoallelic Cartpt deletion) ( Supplemental Figure 11 ).
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ATRX silences Cartpt expression in osteoblastic cells during skeletal development.
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With high efficiency in Cartpt deletion ( Figure 6E ), Rankl showed an increasing trend while Opg expression revealed a decreasing trend in Atrx-cKO BMSCs ( Figure 6, F and G ).