Both IgG2a ( Fig 2A ) and IgG1 ( Fig 2B ) antibodies against the gD2 protein were induced by Ad35.HSV.gD2, and differences between one- and two-dose regimens did not reach statistical significance.
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A replication-incompetent adenoviral vector encoding for HSV-2 gD2 is immunogenic and protective against HSV-2 intravaginal challenge in mice.
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