Longitudinal trends in testicular volume z scores from puberty to adulthood, sperm quality, and paternity outcomes after childhood cancer.

Cancer · 2025 · PMC11694234 · PMID 39470456

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.0780

boldest claim

The sentences

approached significancep = .078so close (0.05 < p ≤ 0.1)

In multivariable analyses, testicular radiation ≥1 Gy (median dose, 12 Gy) and a CED of ≥12 g/m 2 were independent risk factors for having azoospermia in adulthood, whereas a longer interval since the completion of cancer therapy approached significance as a protective factor ( p = .078).

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an increasing trendno p-value reported

An increasing trend in total sperm counts also occurred in repeated semen samples from patients treated exclusively with chemotherapy (Figure 3B ).

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