Evaluation of hypoxia-inducible factor-1α and urine non-transferrin-bound iron concentrations in cats with chronic kidney disease.

Despite there being no significant difference in these concentrations, the variation in uNTBI concentrations does represent an elevated trend as CKD severity increases ( Figure 2B ). 3.5 Spearman and partial correlation Analysis of the Spearman’s rank test demonstrated a significantly positive correlation of pHIF-1α concentrations with uHIF-1α concentrations (rho = 0.54, p < 0.001) and with systolic arterial blood pressure (rho = 0.26, p = 0.032) ( Table 2 ).

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In the present study, although not statistically significant, plasma HIF-1α concentrations showed a trend of being higher during the early stages of CKD (stages 1–2).

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