Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal cancers and provides therapeutic vulnerability.

This analysis revealed a highly significant positive correlation (R 2 = 0.76; p < 0.0001) between the two scores in tumours, suggesting that both biological characteristics are present simultaneously in the same samples, rather than being averaged across them (Fig. 4d ).

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In this light it is interesting to note that stratification of CRC patients into CMSs revealed that CMS3 patients experienced the greatest benefit of 5-FU monotherapy in both stage 2 and stage 3 disease as compared to the other subtypes, although these observations did not reach statistical significance due to small numbers (Supplementary Fig. 8c ).

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