Although the collagen-1/BME-embedded spheroids showed a trend toward a higher expression of accessible integrin per cell compared to nonsupplemented spheroids ( Figure 9 B), an effect of the differential integrin expression of the different spheroid types on IC 50 values should not be present as the replacement of an individual [ 125 I]I-echistatin molecule from the receptor by a NODAGA-PEG 5 -c(RGDfK) molecule should not be influenced by the number of accessible α v β 3 integrins.
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Are 3D Tumor Cell Spheroids a Utile System for the In Vitro Evaluation of Diagnostic Radiotracers?
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