highly significantp -value < 0.001
This difference was highly significant in a simple two-group comparison ( p -value < 0.001).
This difference was highly significant in a simple two-group comparison ( p -value < 0.001).
Secondary outcomes Overall, across secondary outcomes there was an average trend towards better performance in the COB-MS group, though as can be seen below many of these differences did not reach statistical significance at week 12 (with the exception of the MFIS, MSQOL-54 and GHQ questionnaires).