OPG promotes lung metastasis by reducing CXCL10 production of monocyte-derived macrophages and decreasing NK cell recruitment.

Combined analysis of the patients AURORA and RAP datasets revealed that, although the difference did not reach statistical significance due to the limited sample size, the expression of TNFRSF11B was showing a trend of negatively correlated with activated NK cells ( Fig. 7 c).To confirm the hypothesis that OPG promotes lung metastasis by driving the paucity of NK cells, we depleted NK cells using an α-NK1.1 antibody and then injected OPG-KD B16F10 cells.

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