Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding.

As already observed in RNAseq ( Figure 5A ), PAX3 and PAX7 showed a modest, although statistically significant, decrease in affected samples, while MYF5 , MYOD , and MYOG showed a trend toward a greater decrease, which was validated by RT-qPCR MYOG and PAX7 by RT-qPCR ( Figure 5B ).

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The most highly significant function, with a negative normalized enrichment score (NES), downregulated in affected versus non-affected MuSCs samples, was related to proliferation (E2F targets and G2/M checkpoint, Figure 4C ), as well as terms related to myogenesis (muscle structure development, cell, myotube, and myotube differentiation) ( Figure 4C ).

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