The effect of the endothelin receptor antagonist atrasentan on insulin resistance in phenotypic clusters of patients with type 2 diabetes and chronic kidney disease.

Diabetes Obes Metab · 2025 · PMC11701200 · PMID 39503150

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did not reach statistical significanceno p-value reported

This effect of atrasentan was more pronounced in clusters characterized by insulin resistance or deficiency: (SIRD cluster 26.2% [95% CI 3.8,43.3] and SIDD cluster 18.5% [95%CI −3.8,35.9]), although the latter did not reach statistical significance.

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