Mutation impact on mRNA versus protein expression across human cancers.

Based on the number of mutations and genes identified, CRC and UCEC reached statistically significant differences between concordant and all other expressed genes (Wilcoxon rank-sum tests, P = 0.0056 and P = 0.022, respectively); in CRC, mRNA–protein correlations also showed significant differences between discordant and all other expressed genes ( P = 0.013 and P = 0.29, respectively); other cancer types likely did not reach statistical significance likely due to sufficient mutations identified.

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