Efficacy of high-dose versus low-dose tranexamic acid for reduction of blood loss in adolescent idiopathic scoliosis surgery: A systematic review and meta-analysis.

Third, the small sample size and retrospective nature of our studies limited the level of evidence presented in the pooled results, and the statistical analysis failed to reach significance.

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While both groups maintained stable postoperative hemoglobin levels, the high-dose group exhibited a statistically significant reduction in EBL and showed a trend toward fewer transfusions of blood products overall.

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