Quantification Supports Amyloid PET Visual Assessment of Challenging Cases: Results from the AMYPAD Diagnostic and Patient Management Study.

After disclosure of the quantitative results, we observed improvement in concordance across the 5 readers (κ before disclosure, 0.65; 95% CI, 0.55–0.74, 65.3% agreement; κ after disclosure, 0.74; 95% CI, 0.64–0.82, 73.3% agreement), which can be appreciated in the Figure 3 postdisclosure column, where relatively more cases were consistently visually negative or visually positive for all readers, although improvement in reader agreement did not reach statistical significance based on the bootstrapping-derived 95% CI of the κ metric.

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