Comparative efficacy of GLP-1 RAs/SGLT-2 inhibitors in reducing cardiovascular events in type 2 diabetes according to baseline use of metformin: a systematic review and meta-analysis of randomized controlled trials.

Eur J Med Res · 2025 · PMC11706166 · PMID 39773332

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0.0661

closest p · 1.3× alpha

0.0661

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The sentences

did not reach statistical significanceP = 0.0661so close (0.05 < p ≤ 0.1)

Meta-regression The meta-regression results indicated that the coefficient of MACE for metformin use was estimated as at 0.1436 (95%CI − 0.0095, 0.2967), suggesting a potential positive effect of metformin on the outcome, but did not reach statistical significance ( P = 0.0661).

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