Barely Significant
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The prognostic significance of MYC/BCL2 double expression in DLBCL in the genetic classification era.

Cancer Sci · 2025 · PMC11711038 · PMID 39492801

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showed a trendno p-value reported
However, only ST2 presented with significantly better OS than A53 and showed a trend towards better OS compared to the EZB subtype in DEL patients, whereas the other subtypes did not show significant survival difference (Figure 3F,G ).

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marginal significanceno p-value reported
In the JSPH cohort, DEL was noticeably associated with a higher ratio of older age ( P = 0.019), elevated serum lactate dehydrogenase (LDH) level ( P = 0.027), and ABC‐like cell of origin ( P = 0.026), while high‐risk IPI ( P = 0.057) showed marginal significance (Table 1 ).

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borderline significanceno p-value reported
In the JSPH cohort, the mutation frequencies of FAT4 ( P = 0.052) and KMT2D ( P = 0.058) were higher in DEL patients with borderline significance in the MCD subtype (Figure 2D ), and in the OTHER subtype, CD83 exhibited a higher mutation frequency in DEL patients (33.3%) than in non‐DEL patients (2.0%), but there were few DEL patients of the EZB subtype in the JSPH cohort for further mutation analysis.

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