Barely Significant
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Targeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.

Addict Biol · 2025 · PMC11714170 · PMID 39783881

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hedged sentence
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closest p · 1.2× alpha
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boldest claim

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nearly significantp = 0.06so close (0.05 < p ≤ 0.1)
We excluded one participant as an outlier (with PPI = 5.62, VAS‐before = 86, VAS‐after = 95), however, the Pearson correlation results remained nearly significant (R = 0.24, p = 0.06). 4 DISCUSSION Here, we explained how structural and functional MRI can be used to design an experiment and target a VMPFC‐amygdala circuit in people with SUD (Figure 1 ).

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