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Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene.

PLoS Pathog · 2025 · PMC11717313 · PMID 39787208

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showed a trendno p-value reported
In accordance with what we found in PXB-cells infection, subtype A2 showed a trend of higher HBV markers in early stage of infection process (before week 12).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.