Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis of randomized controlled trials.

Although the results of this meta-analysis showed no statistically significant difference, the trial arm showed a slight trend toward tumor-downstaging benefits [RR = 0.99, 95% CI (0.85, 1.15), P = 0.92].

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3.6 Surgical indicators: surgery R0 resection rate, sphincter preservation rate, and surgery complication rate 4 RCTs ( 11 – 14 ) reported surgery R0 resection rates for assessment; there were similarities between the SCRT and LCCRT arms [RR = 1.01, 95% CI (0.98, 1.04), P = 0.55; I 2 = 0%; a fixed-effect model was utilized, shown in Figure 8 ], which were close to borderline significance.

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