Results Our result shows that hypermethylation in site 2 of the CYP2R1 gene with body weight ( p < 0.004), BMI ( p < 0.002), waist circumference ( p < 0.002), total-LDL ( p < 0.027), total cholesterol ( p < 0.022), and vitamin D (VD) (close to borderline significance p < 0.06) and site 4 of CYP2R1 with LDL ( p < 0.041) in the four tested sites among normal and obese women was significantly associated.
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“close to borderline significance”
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p=0.072
In the literature
A 2-year follow-up cohort study showed that depressive symptoms significantly increased the risk of unexplained falls and the association with accidental falls was only close to borderline significance ( 12 ).
When adjusting for the effect of the single nucleotide variations (SNVs) with the strongest associations, the remaining genome-wide associations, if any, were close to borderline significance, indicating strong linkage disequilibrium between these SNVs.
3.6 Surgical indicators: surgery R0 resection rate, sphincter preservation rate, and surgery complication rate 4 RCTs ( 11 – 14 ) reported surgery R0 resection rates for assessment; there were similarities between the SCRT and LCCRT arms [RR = 1.01, 95% CI (0.98, 1.04), P = 0.55; I 2 = 0%; a fixed-effect model was utilized, shown in Figure 8 ], which were close to borderline significance.