Interestingly, young and old male MK CM increased total vessel length of female BMECs and demonstrated a strong trend toward increasing total number of vessels ( Figure 3A , 3B , 3E – 3G ).
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The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells.
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When male BMECs were treated with male MK CM, only non-significant increases were observed ( Figure 1A ); female BMECs, however, proliferated significantly more with young male MK CM treatment and almost reached significance with old male MK CM treatment ( Figure 1C ).