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Effect of Genetic Variants on Rosuvastatin Pharmacokinetics in Healthy Volunteers: Involvement of <i>ABCG2</i>, <i>SLCO1B1</i> and <i>NAT2</i>.

Int J Mol Sci · 2024 · PMC11720188 · PMID 39796117

Europe PMCDOI
1
hedged sentence
0.0600
closest p · 1.2× alpha
0.0600
boldest claim

The sentences

a clear trendp = 0.060so close (0.05 < p ≤ 0.1)
Additionally, a clear trend of increased AUC ∞ /DW (613.46 ± 220.42 h*ng*kg/mL*mg, p = 0.060) and C max /DW (57.69 ± 22.19 ng*kg/mL*mg, p = 0.067) was also observed for SLCO1B1 DFs + PFs in comparison to IFs + NFs (530.36 ± 223.98 h*ng*kg/mL*mg for AUC ∞ /DW; and 49.59 ± 22.09 ng*kg/mL*mg for C max /DW) ( Table 3 ).

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