Integrated Analysis of Cell-Free DNA and Novel Protein Biomarkers for Stratification and Therapy Monitoring in Stage IV Pancreatic Cancer: A Preliminary Study.

Diagnostics (Basel) · 2024 · PMC11720586 · PMID 39795577

Europe PMC DOI

hedged sentence

0.0775

closest p · 1.5× alpha

0.0775

boldest claim

The sentences

showed a trendp = 0.0775so close (0.05 < p ≤ 0.1)

High KRAS mut cfDNA levels (>25 copies/mL) before the start of systemic chemotherapy were inversely associated with PFS (HR = 2.07, 95% CI: 1.011–4.229, p = 0.0057; Supplemental Figure S2A ) and also showed a trend toward inferior OS (HR = 1.72, 95% CI: 0.850–3.489, p = 0.0775; Supplemental Figure S2B ).

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