Late-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study.

Late-life physical activity levels and cognition impairment Compared to those with low PA levels, participants with moderate (odds ratio [OR] = 0.74, 95% confidence interval [CI] = 0.55 ~ 0.99, P -value = 4.16 × 10 − 2 ) and high PA levels (OR = 0.60, 95%CI = 0.48 ~ 0.75, P -value = 6.35 × 10 − 6 ) demonstrated significantly lower risk of cognitive impairment, with an increasing trend from moderate to high PA level group ( P -trend = 6.57 × 10 − 6 , Fig. 2 and Supplementary Table 1 ).

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Notably, although our results indicated a protective trend for increasing activity levels from midlife to late life, this association did not reach statistical significance, warranting further verification in future studies.

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