Fructose-Induced Metabolic Dysfunction Is Dependent on the Baseline Diet, the Length of the Dietary Exposure, and Sex of the Mice.

Fructose Supplementation in Female Mice More Strongly Upregulates KHK-C and DNL Enzymes than in Males Similar to males, female mice supplemented with fructose showed a trend toward an increase in liver weight compared to those receiving regular water (1.40 ± 0.09 g vs. 1.20 ± 0.08 g) ( Figure 6 A).

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