Luminal epithelial cells integrate variable responses to aging into stereotypical changes that underlie breast cancer susceptibility.

Because we expected the signal in bulk tissue to be muted due to cellular heterogeneity, we also evaluated leading edge genes that showed nominally significant DE between younger and older tissue (unadj. p<0.05) ( Figure 5—source data 1A ).

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p < 0.001, absolute log 2 fold change (abs(lfc)) ≥1), we found 4,040 genes (23% of all genes analyzed) with highly significant lineage-specific DE in younger women ( Figure 1—source data 2A ) and ( Figure 1—source data 3A ).

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