Adequacy of EUS-guided fine-needle aspiration and fine-needle biopsy for next-generation sequencing in pancreatic malignancies: A systematic review and meta-analysis.

Pooled proportions were higher in studies using end-cutting needles (97.1%; 95% CI, 88.5%–100.0%; I 2 = 75.0%) than FNA (89.1%; 95% CI, 73.8%–98.9%; I 2 = 87.7%) or Procore needles (83.4%; 95% CI, 22.3%–100.0%; I 2 = 97.4%) ( P = 0.372), in studies using ≤22-gauge needles (87.4%; 95% CI, 73.6%–97.1%; I 2 = 90.5%) than 25-gauge needles (51.2%; 95% CI, 4.6%–96.6%; I 2 = 94.9%, P = 0.130), and in studies with application of rapid on-site evaluation (ROSE) (99.1%; 95% CI, 94.0%–100.0%; I 2 = 62.1%) than those without (88.7%; 95% CI, 66.5%–99.9%; I 2 = 94.32%, P = 0.183), but the differences did not reach statistical significance (Figures S1–S3, http://links.lww.com/ENUS/A364 ).

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