Barely Significant
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Genomic characterization of Huntington's disease genetic modifiers informs drug target tractability.

Brain Commun · 2025 · PMC11724427 · PMID 39801710

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closest p · 1.0× alpha
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nominally significantP < 0.05actually significant
CCDC82 , LIG1 , MSH3 , PMS1 and PMS2 all displayed nominally significant associations ( P < 0.05) in the XDP AOO GWAS, and it should be noted that variants related to FAN1 and RRM2B have also previously been associated with AOO in polyglutamine disorders. 21 Diverse human diseases and traits are associated with Huntington’s disease modifier genes A total of five Huntington’s disease modifier genes ( FAN1 , MLH1 , MSH3 , PMS2 and RRM2B ) had OMIM phenotype entries, mainly for cancer-related diseases for DNA-repair-related genes ( Table 1 ).

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