IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis.

J Inflamm Res · 2025 · PMC11725275 · PMID 39802515

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0.0520

closest p · 1.0× alpha

0.1500

boldest claim

The sentences

marginally significantp =0.052so close (0.05 < p ≤ 0.1)

As shown in Table 3 , Supplementary Table 3 and Supplementary Table 4 , the ACME of IL-8 was statistically significant for PFS ( p =0.036) and was marginally significant for OS ( p =0.052).

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marginal significancep =0.08so close (0.05 < p ≤ 0.1)

Consistent with our result from GZBCS mentioned earlier in this paper, breast cancer patients with low IL-8 signaling had better prognosis with marginal significance ( p =0.08, Figure 3A ).

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did not reach statistical significancep =0.15not close (p > 0.1)

In contrast, the association between IL-8 and breast cancer prognosis did not reach statistical significance among patients with high levels of IL-2 signaling ( p =0.15, Figure 3E ), IL-12 signaling ( p =0.17, Figure 3F ) or IL-7 signaling ( p =0.2, Figure 3G ).

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