HLA-DQA1*05 Associates With Anti-Tumor Necrosis Factor Immunogenicity and Low Adalimumab Trough Concentrations in Inflammatory Bowel Disease Patients From the SERENE Ulcerative Colitis and Crohn's Disease Studies.

J Crohns Colitis · 2025 · PMC11725519 · PMID 39162746

Europe PMC DOI

hedged sentence

0.0050

closest p · 0.1× alpha

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approached significancep = 0.005actually significant

DQA1*05:05 carriage approached significance for endoscopic remission at the Week 52 timepoint in SERENE UC (odds ratio 0.545, p = 0.005), and the allele had a consistent direction of effect, lowering the odds of a patient being in remission, in all tests except clinical remission in the smallest cohort (SERENE CD, Week 56: 153 patients).

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