Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endothelium.

DMSO alone reduced TNF production in a dose‐dependent manner; however, the decrease was almost significant only at the highest concentration (34.85%, P = 0.05) (Supplementary Figure 1 ).

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Further, tofacitinib treatment at 1 μM decreased endothelial TF expression compared with DMSO‐treated cocultures (0.86 vs 1.32); this reduction, however, did not reach statistical significance.

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