MIF Inhibition by ISO-1 Decreased Autophagic Activity in Primary Astrocytes During Cobalt Chloride-Induced Hypoxia.

Although MIF protein levels did not show statistically significant differences among all groups at 6 h of treatment, at 24 h, there was a slight increase in MIF protein levels in the group treated with 500 μM cobalt chloride alone and in the group co-treated with 500 μM cobalt chloride and ISO-1; however, this increase did not reach statistical significance ( Figure 4 A,B,D,E).

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