Alpha-Lipoic Acid-Mediated Inhibition of LTB<sub>4</sub> Synthesis Suppresses Epithelial-Mesenchymal Transition, Modulating Functional and Tumorigenic Capacities in Non-Small Cell Lung Cancer A549 Cells.

Curr Ther Res Clin Exp · 2025 · PMC11731977 · PMID 39816494

Europe PMC DOI

hedged sentence

0.2633

closest p · 5.3× alpha

0.2633

boldest claim

The sentences

showed a trendP = 0.2633not close (p > 0.1)

We demonstrated that preincubation with SC-57461A, a selective inhibitor of LTA 4 H, increased the expression levels of E-cadherin compared to stimuli with LTB 4 (Kruskal-Wallis Test; P = 0.0103; Figures 5 A and B), however, 10 μM of ALA showed a trend towards increased expression of the epithelial marker (Kruskal-Wallis Test; P = 0.2633; Figures 5 A and B).

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