Pharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients.

Heliyon · 2025 · PMC11732454 · PMID 39811327

Europe PMC DOI

hedged sentences

0.1660

closest p · 3.3× alpha

0.1660

boldest claim

The sentences

did not reach statistical significancep = 0.166not close (p > 0.1)

Other haplotypes such as A∗24:02B∗35:01DRB1∗13:01 and A∗01:01B∗15:02DRB1∗13:01 were also found exclusively in cases, and they did not reach statistical significance (p = 0.166).

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highly significantno p-value reported

For AED-induced TEN, HLA-A∗01:02 , HLA-B∗15:02, and HLA-B∗52:01 showed significant associations (OR = 6.92; 95 % CI: 1.39–34.37 and OR = 6.55; 95 % CI: 1.62–26.52, respectively), with HLA-DRB1∗03:01 being highly significant (OR = 5.09; 95 % CI: 1.72–15.00).

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