Impact of myelodysplasia-related and additional gene mutations in intensively treated patients with <i>NPM1</i>-mutated AML.

Hemasphere · 2025 · PMC11733593 · PMID 39816531

Europe PMC DOI

hedged sentence

0.0010

closest p · 0.0× alpha

0.0010

boldest claim

The sentences

highly significantp < 0.001actually significant

showed a trendp < 0.001actually significant

The cohesin complex genes RAD21 ( p = 0.052), SMC1A (0.093), and SMC3 (0.053) showed a trend toward improved EFS, and when all cohesin genes ( RAD21 , SMC1A , SMC3 , STAG2 ) were grouped the effect was statistically highly significant ( p < 0.001).

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